Available as:
Indications
Maxbuten Syrup is used for:
Respiratory tract infections, Urinary tract infections, Acute Bacterial Exacerbations of Chronic Bronchitis, Acute Bacterial Otitis Media, Pharyngitis and Tonsillitis
Adult Dose
Oral
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Child Dose
Child:
<6 months: Safety and efficacy not established
6-12 years old or <45 kg: 9 mg/kg PO once daily; 400 mg/day PO for 10 days maximum
>12 years old or >45 kg: 400 mg once daily for 10 days.
Renal Dose
Renal Impairment
CrCl 30-49 mL/min: 200 mg PO qDay or 4.5 mg/kg qDay
CrCl 5-29 mL/min: 100 mg PO qDay or 2.25 mg/kg qDay
Supplement following hemodialysis
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals.
Cap: May be taken with or without food.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Hypersensitivity to penicillins; renal impairment; Porphyria.
Diabetics: oral suspension contains 1 g sucrose/tsp
Modify dosage in severe renal impairment;
prolonged use may result in superinfection;
caution in seizure disorder;
may cause antibiotic-associated colitis
Monitor renal and haematologic status.
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interactions
Enhanced nephrotoxicity of aminoglycosides.
Increased serum concentration w/ probenecid.
Decreased serum concentration w/ zinc salts.
Contraindicated (0)
Serious (4)
BCG vaccine live
cholera vaccine
microbiota oral
typhoid vaccine live
Adverse Effects
Side effects of Ceftibuten :
1-10%
Increased BUN (4%),Nausea (4%),Diarrhea (3%),Headache (3%),Increased eosinophils (3%),Decreased hemoglobin (2%),Dyspepsia (2%),Thrombocytosis (2%),Abdominal pain (1%),Dizziness (1%),Increased ALT (1%),Increased bilirubin (1%),Vomiting (1%)
<1%
Anorexia,Candidiasis,Constipation,Dysuria,Agitation,Fatigue,Insomnia,Irritability,Paresthesia,Rigors,Diaper rash,Urticaria,Dry mouth,Dyspnea,Nasal congestion,Increased transaminases,Increased creatinine,Leukopenia
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Note
Maxbuten 90 mg/5 ml Syrup manufactured by Synovia Pharma PLC. Its generic name is Ceftibuten. Maxbuten is availble in Bangladesh.
DIMS information on Maxbuten Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.