Indications
Amenavir Tablet is used for:
Herpes simplex, herpes zoster
Adult Dose
Adult
Oral
Herpes simplex: The usual adult dosage of Amenavir is 200 mg administered orally once daily after meal.
Recurrent herpes simplex: 1200 mg single dose after meals within 6 hours after the appearance of the initial symptoms of recurrent herpes simplex. (Only one dose is required).
Herpes zoster: The usual adult dosage of Amenavir is 400 mg administered orally once daily after meal.
Child Dose
Renal Dose
Renal Impairment
Mild to Moderate (eGFR ? 30 mL/min/1.73 m²):
No dose adjustment required.
Severe (eGFR < 30 mL/min/1.73 m²):
Limited data; exposure may increase — use with caution and monitor renal function.
End-Stage Renal Disease / Dialysis:
Not studied; avoid use or use only if benefits outweigh potential risk.
Administration
Contra Indications
Known hypersensitivity or allergy to amenamevir or any of its components.
Severe Renal Impairment.
Precautions
Hepatic or renal impairment: Limited clinical data; use with caution and monitor function.
Special monitoring is essential for patients with the following clinical conditions:
Severe renal impairment
Thrombocytopenia
Elderly patients
Pregnancy-Lactation
Pregnancy: Insufficient human data; use only if potential benefit justifies possible risk.
Lactation: Limited data; small transfer into breast milk reported (estimated RID < 10%).
Interactions
Amenavir has notable interactions with certain drugs due to its metabolism via cytochrome P450 enzymes, particularly CYP3A4.
Ketoconazole: As a strong CYP3A4 inhibitor, Ketoconazole significantly increases the plasma concentration of Amenavir.
Rifampicin:This strong CYP3A4 inducer markedly decreases Amenavir levels, that could lead to reduced efficacy of Amenavir.
Midazolam: As a substrate of CYP3A4, Midazolam's pharmacokinetics are affected by Amenavir, leading to decreased plasma levels when both are taken together.
Warfarin: No significant interaction was observed between Amenavir and Warfarin, a medication metabolized by CYP2C9.
Live viral vaccines: May reduce vaccine efficacy; concurrent use not recommended.
Caution with drugs affecting hepatic metabolism or renal excretion.
Adverse Effects
Side effects of Amenamevir :
Common: Nausea, diarrhea, headache, nasopharyngitis, sore throat.
Uncommon/Post-marketing: Thrombocytopenia, gingival bleeding, palpitations.
Mechanism of Action
Helicase-Primase Inhibitor:
Blocks the helicase-primase complex essential for viral DNA replication in HSV and VZV, inhibiting viral genome synthesis and replication.
Note
Amenavir 200 mg Tablet manufactured by Square Pharmaceuticals PLC.. Its generic name is Amenamevir. Amenavir is availble in Bangladesh.
DIMS information on Amenavir Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.