A Clox

Precaution

Patient w/ allergies esp β-lactam allergy, asthma, history of seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Observe for signs and symptoms of anaphylaxis during 1st dose. Monitor CBC w/ differential (prior to initiating therapy and wkly thereafter), periodic BUN, creatinine, hepatic function.

Indication

Staphylococcal infections resistant to benzylpenicillin

Adult Dose

Oral Adult: 250-500 mg 4 times/day. Parenteral Adult: 1-2 g 6 hrly. For more severe infections (e.g. meningitis, endocarditis), 2 g 4 hrly.

Child Dose

Oral Child: 50-100 mg/kg in divided doses every 6 hr.

Administration

Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Reconstitution: IM: The contents of each vial should be dissolved in 1.5 mL of water for inj. IV: 500 mg to be dissolved in 10-20 mL of water for inj, added to suitable IV fluids if given for i

Side Effect

Hypotension, confusion, fever, lethargy, seizure, pruritus, rash, urticaria, abdominal pain, black or hairy tongue, diarrhoea, flatulence, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting, agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, haemolytic anaemia, leucopenia, neutropenia, thrombocytopenia, increased alkaline phosphatase, ALT and AST, hepatotoxicity, thrombophlebitis, arthralgia, myalgia, myoclonus, hematuria, interstitial nephritis, proteinuria, renal insufficiency, renal tubular damage, bronchospasm, laryngeal oedema, laryngospasm, sneezing, wheezing, angioedema, allergic reaction, serum sickness-like reaction. Potentially Fatal: Anaphylaxis.

Interaction

May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.